After Henrietta barely surives the savage murder of her family, Italy's Social Welfare Agency takes her in and repairs her injuries using the latest in cybernetic technology. All traces of Henrietta's past are wiped from her mind as she becomes one of the Agency's most lethal assassins.

Despite her progamming, Henrietta is troubled by fragmented memories. Her handler Jose must keep her feelings in check and ensure that she stays on mission; a task made all the more difficult by Henrietta's striking resemblance to Jose's late younger sister.

Collects volumes 1-3 of Gunslinger Girl in an omnibus edition.

Story and art by Yu Aida.